2010 Kremlin Cup should not be confused with 2010 Kazan Kremlin Cup.
The 2010 Kremlin Cup was a tennis tournament played on indoor hard courts. It was the 21st edition of the Kremlin Cup for the men (15th edition for the women) and was part of the ATP World Tour 250 Series of the 2010 ATP World Tour, and of the Premier Series of the 2010 WTA Tour. It was held at the Olympic Stadium in Moscow, Russia, from 18 October through 24 October 2010. Viktor Troicki and Victoria Azarenka won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Nikolay Davydenko | 6 | 1 | ||
| Mikhail Youzhny | 8 | 2 | ||
| Jo-Wilfried Tsonga | 13 | 3 | ||
| Marcos Baghdatis | 18 | 4 | ||
| Radek Štěpánek | 30 | 5 | ||
| Andrey Golubev | 33 | 6 | ||
| Sergiy Stakhovsky | 34 | 7 | ||
| Janko Tipsarević | 37 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a Lucky loser into the singles main draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Jelena Janković | 7 | 1 | ||
| Victoria Azarenka | 10 | 2 | ||
 China | Li Na | 11 | 3 | |
| Anastasia Pavlyuchenkova | 21 | 4 | ||
| Flavia Pennetta | 23 | 5 | ||
| Maria Kirilenko | 24 | 6 | ||
| Alisa Kleybanova | 26 | 7 | ||
 Spain | María José Martínez Sánchez | 27 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Kremlin Cup – Men's singles. 
Viktor Troicki defeated 
Marcos Baghdatis, 3–6, 6–4, 6–3.
See main article: 2010 Kremlin Cup – Women's singles. 
Victoria Azarenka defeated 
Maria Kirilenko, 6–3, 6–4.
See main article: 2010 Kremlin Cup – Men's doubles. Igor Kunitsyn / Dmitry Tursunov defeated Janko Tipsarević / Viktor Troicki, 7–6(10–8), 6–3.
See main article: 2010 Kremlin Cup – Women's doubles. 
Gisela Dulko / 
Flavia Pennetta defeated Sara Errani / María José Martínez Sánchez, 6–3, 2–6, [10–6].
