See main article: 2010 Karshi Challenger. Sadik Kadir and Purav Raja were the defending champions, but they lost to Murad Inoyatov and Andrey Kumantsov in the first round.
Gong Maoxin and Li Zhe won the title, by defeating Divij Sharan and Vishnu Vardhan 6–3, 6–1 in the final.