| Year: | 2010 |
| Team: | Jackson State Tigers |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Division: | East Division |
| Short Conf: | SWAC |
| Record: | 8–3 |
| Conf Record: | 6–3 |
| Head Coach: | Rick Comegy |
| Hc Year: | 5th |
| Stadium: | Mississippi Veterans Memorial Stadium |
| Champion: | SWAC East Division co-champion |
The 2010 Jackson State Tigers football team represented Jackson State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2010 NCAA Division I FCS football season. Led by fifth-year head coach Rick Comegy, the Tigers compiled an overall record of 8–3 with a mark of 6–3 in conference place, sharing the SWAC East Division title with Alabama State.