The 2010 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts. It was the ninth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Champaign, United States between 15 and 21 November 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Japan | Kei Nishikori | 120 | 1 | |
 Australia | Peter Luczak | 143 | 2 | |
| Australia | Carsten Ball | 154 | 3 | |
| Izak van der Merwe | 172 | 4 | ||
| Bobby Reynolds | 180 | 5 | ||
| Alex Bogomolov Jr. | 198 | 6 | ||
| Lester Cook | 208 | 7 | ||
 Ecuador | Giovanni Lapentti | 218 | 8 |
The following players received wildcards into the singles main draw:
Amer Delić
Steve Johnson Dennis Nevolo Abraham SouzaThe following players received a Special Exempt into the singles main draw:
The following players received entry from the qualifying draw:
See main article: article and 2010 JSM Challenger of Champaign–Urbana – Singles. Alex Bogomolov Jr. def. Amer Delić, 5–7, 7–6(7), 6–3
See main article: article and 2010 JSM Challenger of Champaign–Urbana – Doubles. Raven Klaasen / Izak van der Merwe def. Ryler DeHeart / 
Pierre-Ludovic Duclos, 4–6, 7–6(2), [10–4]
