The 2010 Internationaux de Strasbourg was a tennis tournament played on an outdoor clay court. It was the 24th edition of the Internationaux de Strasbourg, and was part of the International-level tournaments of the 2010 WTA Tour. It took place at the Centre Sportif de Hautepierre in Strasbourg, France, from 17 May until 22 May 2010.
| Player | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Maria Sharapova |  Russia | 12 | 1 | |
| Elena Vesnina | Russia | 34 | 2 | |
| Virginie Razzano |  France | 47 | 3 | |
| Peng Shuai |  China | 50 | 4 | |
| Anabel Medina Garrigues |  Spain | 54 | 5 | |
| Sybille Bammer |  Austria | 59 | 6 | |
| Anastasija Sevastova | Latvia | 60 | 7 | |
| Elena Baltacha |  United Kingdom | 62 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received the lucky loser spot:
See main article: 2010 Internationaux de Strasbourg – Singles. Maria Sharapova defeated Kristina Barrois, 7–5, 6–1
See main article: 2010 Internationaux de Strasbourg – Doubles. Alizé Cornet / 
Vania King defeated Alla Kudryavtseva / 
Anastasia Rodionova, 3–6, 6–4, [10–7]