See main article: InterLiga 2010. After both finals have been played, both winners qualify to the Copa Libertadores. Of the two winners, the team with the highest points during the group stages will be dubbed "Mexico 2"
Kickoffs are given in (UTC-6).
| PUEBLA: | ||||
| width=25 | ! | width=25 | ||
|---|---|---|---|---|
| GK | 1 |  Jorge Villalpando | ||
| RB | 2 | |||
| CB | 5 | Álvaro Ortiz | ||
| SW | 23 | Joaquín Velázquez | ||
| CB | 3 | Alejandro Acosta | ||
| LB | 11 | |||
| DM | 14 | Luis Miguel Noriega (c) | ||
| DM | 6 | Marcelo Palau | ||
| LW | 10 | Nicolás Olivera | ||
| RW | 20 | Carlos Ruíz | ||
| FW | 13 | |||
| Substitutes: | ||||
| GK | 33 | Alexandro Álvarez | ||
| DF | 26 | Roberto Juárez | ||
| MF | 7 | Sergio Rosas | ||
| MF | 29 | |||
| MF | 30 | Felipe Ayala | ||
| MF | 22 | Pablo Aja | ||
| FW | 9 | |||
| Manager: | ||||
| José Luis Sánchez Solá | ||||
| ESTUDIANTES TECOS: | ||||
| width=25 | ! | width=25 | ||
|---|---|---|---|---|
| GK | 23 | Mario Rodríguez | ||
| RB | 6 | |||
| CB | 2 | Oswaldo Alanís | ||
| SW | 27 | Juan Carlos Leaño (c) | ||
| CB | 21 | Diego Jiménez | ||
| LB | 7 | Daniel Alcántar | ||
| DM | 18 | |||
| DM | 20 | Elgabry Rangel | ||
| RW | 11 | |||
| LW | 14 | |||
| FW | 16 | |||
| Substitutes: | ||||
| GK | 1 | Fabián Villaseñor | ||
| DF | 8 | |||
| DF | 25 | José Ramón Partida | ||
| DF | 58 | Emerson Lomelí | ||
| MF | 5 | |||
| MF | 10 | |||
| FW | 9 | Roberto Gutiérrez | ||
| Manager: | ||||
| Miguel Herrera | ||||
Assistant referees: Fabio Tovar Héctor VergaraFourth official: Kevin Stott |
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| AMÉRICA: | ||||
| width=25 | ! | width=25 | ||
|---|---|---|---|---|
| GK | 1 | Guillermo Ochoa | ||
| RB | 4 | Óscar Rojas | ||
| CB | 6 | Juan Carlos Valenzuela | ||
| CB | 3 |  Aquivaldo Mosquera | ||
| LB | 15 | |||
| RW | 21 | |||
| DM | 5 | |||
| DM | 13 | Pável Pardo (c) | ||
| LW | 29 | Jean Beausejour | ||
| SS | 11 |  Daniel Montenegro | ||
| CF | 10 | Salvador Cabañas | ||
| Substitutes: | ||||
| GK | 36 | Alfonso Blanco | ||
| DM | 14 | Jesús Sánchez | ||
| MF | 18 | |||
| MF | 23 | Joaquín Martínez | ||
| MF | 26 | Juan Carlos Silva | ||
| MF | 7 | |||
| FW | 24 | Daniel Márquez | ||
| Manager: | ||||
| Jesús Ramírez | ||||
| MONTERREY: | ||||
| width=25 | ! | width=25 | ||
|---|---|---|---|---|
| GK | 1 | |||
| RB | 2 | |||
| CB | 19 | Héctor Morales | ||
| CB | 15 | José Basanta | ||
| LB | 22 | William Paredes | ||
| DM | 6 | |||
| CM | 8 | Luis Ernesto Pérez (c) | ||
| LW | 20 |  Walter Ayoví | ||
| RW | 18 | |||
| SS | 10 | Osvaldo Martínez | ||
| CF | 13 | |||
| Substitutes: | ||||
| GK | 25 | Omar Ortíz | ||
| DF | 5 | Duilio Davino | ||
| MF | 21 | |||
| MF | 7 | Juan Carlos Medina | ||
| MF | 28 | Jesús Arellano | ||
| FW | 9 | |||
| FW | 11 | |||
| Manager: | ||||
| Víctor Manuel Vucetich | ||||
Assistant referees: Corey Rockwell Frank de BleeckereFourth official: Ramón Hernández |