| Team: | Hamilton Tiger-Cats |
| Year: | 2010 |
| Record: | 9–9 |
| Division Place: | 2nd, East |
| Coach: | Marcel Bellefeuille |
| General Manager: | Bob O'Billovich |
| Stadium: | Ivor Wynne Stadium |
| Playoffs: | Lost East Semi-Final |
| Mop: | Kevin Glenn |
| Moc: | Dave Stala |
| Mor: | Marcus Thigpen |
| Uniform: | File:CFL HAM Jersey 2010.png |
| Shortnavlink: | Tiger-Cats seasons |
The 2010 Hamilton Tiger-Cats season was the 53rd season for the team in the Canadian Football League and their 61st overall. The Tiger-Cats succeeded in making a second straight playoff appearance, as well as hosting a second straight playoff game, but lost the East Semi-Final to the Toronto Argonauts.
| Round | Pick | Player | Position | School/Club Team |
|---|---|---|---|---|
| 3 | 19 | RB | Laval | |
| 3 | 22 | DT | Manitoba | |
| 4 | 27 | DB | Duke | |
| 5 | 36 | K/P | Saint Mary's | |
| Week | Date | Opponent | Score | Result | Attendance | Record |
|---|---|---|---|---|---|---|
| A | Sun, June 13 | at Toronto Argonauts | 13–10 | Loss | 12,514 | 0–1 |
| B | Sun, June 20 | Winnipeg Blue Bombers | 38–20 | Win | 19,645 | 1–1 |
| Week | Date | Opponent | Score | Result | Attendance | Record |
|---|---|---|---|---|---|---|
| 1 | Fri, July 2 | at Winnipeg Blue Bombers | 49–29 | Loss | 26,302 | 0–1 |
| 2 | Sat, July 10 | Calgary Stampeders | 23–22 | Loss | 25,248 | 0–2 |
| 3 | Fri, July 16 | Winnipeg Blue Bombers | 28–7 | Win | 21,408 | 1–2 |
| 4 | Thurs, July 22 | at Montreal Alouettes | 37–14 | Loss | 25,012 | 1–3 |
| 5 | Sat, July 31 | at Saskatchewan Roughriders | 37–24 | Loss | 30,048 | 1–4 |
| 6 | Sat, Aug 7 | Winnipeg Blue Bombers | 29–22 | Win | 23,653 | 2–4 |
| 7 | Fri, Aug 13 | at Winnipeg Blue Bombers | 39–28 | Win | 27,892 | 3–4 |
| 8 | Fri, Aug 20 | at Toronto Argonauts | 16–12 | Win | 24,493 | 4–4 |
| 9 | colSpan=5 align="center" | Bye | 4–4 | |||
| 10 | Mon, Sept 6 | Toronto Argonauts | 28–13 | Win | 30,319 | 5–4 |
| 11 | Sat, Sept 11 | Montreal Alouettes | 27–6 | Loss | 23,452 | 5–5 |
| 12 | Sat, Sept 18 | at BC Lions | 35–31 | Win | 21,481 | 6–5 |
| 13 | Sat, Sept 25 | Saskatchewan Roughriders | 32–25 | Loss | 23,108 | 6–6 |
| 14 | Sun, Oct 3 | at Edmonton Eskimos | 37–35 | Loss | 34,479 | 6–7 |
| 15 | Fri, Oct 8 | Edmonton Eskimos | 36–11 | Win | 20,791 | 7–7 |
| 16 | Fri, Oct 15 | at Toronto Argonauts | 30–3 | Win | 25,181 | 8–7 |
| 17 | Fri, Oct 22 | Montreal Alouettes | 40–3 | Win | 23,118 | 9–7 |
| 18 | Fri, Oct 29 | at Calgary Stampeders | 55–24 | Loss | 27,644 | 9–8 |
| 19 | Sat, Nov 6 | BC Lions | 23–21 | Loss | 23,913 | 9–9 |