| Competition: | GFF National Super League |
| Season: | 2010 |
| Winners: | Alpha United |
| Relegated: | Bakewell Topp XX Liquid Gold |
| Continentalcup1: | CFU Club Championship |
| Continentalcup1 Qualifiers: | Alpha United Milerock |
| Continentalcup2: | CONCACAF Champions League |
| Continentalcup2 Qualifiers: | Alpha United |
| Biggest Away Win: | Buxton United 1–8 Alpha United (9 Apr. 2011)[1] |
| Prevseason: | 2009 |
| Nextseason: | 2011 |
The 2010 GFF National Super League was the third season of the National Super League under its current format, and the twentieth reported season of top tier Guyanese football. The champions for the second consecutive year were Alpha United who did not lose a single match during the campaign. As champions, Alpha United, along with league runners-up, Milerock earned a berth into the 2011 CFU Club Championship.
The season began in February and ended in September.