See main article: 2010 French Open. Liezel Huber and Bob Bryan were the defending champions, but Bryan chose to not compete this year in mixed doubles.
Huber partnered up with Mahesh Bhupathi, but they lost in the first round against Chan Yung-jan and Eric Butorac.
Katarina Srebotnik and Nenad Zimonjić won in the final 4–6, 7–6(7–5), [11–9], against Yaroslava Shvedova and Julian Knowle.