| Main Name: | Portugal OpenEstoril Open |
| Champ: | Anastasija Sevastova |
| Runner: |  Arantxa Parra Santonja |
| Score: | 6–2, 7–5 |
| Before Name: | Estoril Open – Women's singles |
| After Name: | Estoril Open – Women's singles |
See main article: 2010 Estoril Open. Yanina Wickmayer was the defending champion, but she chose to play in Rome rather than defend 2009 title here.
Anastasija Sevastova won her first WTA singles title, defeating Arantxa Parra Santonja in the final 6–2, 7–5.