| Sport: | football |
| Year: | 2010 |
| Team: | Eastern Illinois Panthers |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 2–9 |
| Conf Record: | 2–6 |
| Head Coach: | Bob Spoo |
| Hc Year: | 23rd |
| Off Coach: | Roy Wittke |
| Oc Year: | 16th |
| Def Coach: | Roc Bellantoni |
| Dc Year: | 9th |
| Stadium: | O'Brien Field |
The 2010 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2010 NCAA Division I FCS football season. Led by 23rd-year head coach Bob Spoo, the Panthers compiled an overall record of 2–9 with a mark of 2–6 in conference play, placing seventh in the OVC.[1] Eastern Illinois played home games at O'Brien Field in Charleston, Illinois.