The 2010 ECM Prague Open, also known as 2010 ECM Prague Open by Glanzis was a tennis tournament played on outdoor clay courts. It was the 9th edition of the ECM Prague Open, and was part of the WTA International tournaments of the 2010 WTA Tour. It took place in Prague, Czech Republic, from July 12 through July 18, 2010.
This was the last edition of ECM Prague Open due to financial distress.[1]
| Player | Nationality | Ranking* | Seeding |
|---|---|---|---|
| Lucie Šafářová |  Czech Republic | 25 | 1 |
| Alexandra Dulgheru |  Romania | 30 | 2 |
| Switzerland | 39 | 3 | |
| Czech Republic | |||
| Anabel Medina Garrigues |  Spain | 46 | 5 |
 Argentina | |||
 Hungary | 49 | 7 | |
| Barbora Záhlavová-Strýcová | Czech Republic | 54 | 8 |
| Patty Schnyder | Switzerland | 56 | |
| Anastasija Sevastova | Latvia | 59--> | |
The following players received wildcards into the singles main draw
The following players received entry from the qualifying draw:
The following players received a lucky loser spot:
See main article: 2010 ECM Prague Open – Singles. Ágnes Szávay defeated Barbora Záhlavová-Strýcová, 6–2, 1–6, 6–2
See main article: 2010 ECM Prague Open – Doubles. Timea Bacsinszky / 
Tathiana Garbin defeated Monica Niculescu / Ágnes Szávay, 7–5, 7–6(7–4)
