The 2010 Copa Venezuela was the 41st staging of the Copa Venezuela.
The competition started on August 25, 2010 and concluded on December 8, 2010 with a two leg final, in which Trujillanos FC won the trophy for the second time with a 0–0 draw at home and a 1–1 draw away over Zamora FC.
NB: Estrella Roja FC decline to take part.
The matches were played on 25–26 August 2010.
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The matches were played on 4–5 September 2010.
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The matches were played on 15 September–6 October 2010.
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The matches were played on 8 October–3 November 2010.
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The matches were played on 10–24 November 2010.
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The matches were played on 1–8 December 2010.
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Trujillanos FC qualify to Copa Sudamericana 2011.
| Player | Club | Goals | |
|---|---|---|---|
| 3 | |||
| Real Bolívar | 3 | ||
| Luis Cabezas (COL) | 3 | ||
| Andrés Buelvas (COL) | 3 | ||
| 3 | |||
| 3 |