See main article: 2010 Copa Sudamericana. The finals stages of the 2010 Copa Sudamericana de Clubes are the Round of 16, Quarterfinals, Semifinals, and Finals. Teams from the Round of 16 onwards were seeded depending on which Second Stage tie they win (i.e. the winner of Match O1 has the 1 seed).
Note: The bracket was adjusted according to the rules of the tournament so that the two Brazilian teams would face each other in the semifinals.
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----San José 3–3 Newell's Old Boys on points. Newell's Old Boys advanced on goal difference.
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Independiente 3–3 Defensor Sporting on points. Independiente advanced on goal difference.
----Peñarol 3–3 Goiás on points. Goiás advanced on away goals.
----Palmeiras advanced on points 6–0.
----Santa Fe 3–3 Atlético Mineiro on points. Atlético Mineiro advanced on goal difference.
----Avaí 3–3 Emelec on points. Avaí advanced on goal difference.
----Deportes Tolima 3–3 Banfield on points. Deportes Tolima advanced on goal difference.
----LDU Quito 3–3 Unión San Felipe on points. LDU Quito advanced on goal difference.
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----LDU Quito advanced on points 4–1.
----Note: The second leg was played at a neutral venue since Independiente received a one-match stadium ban after crowd trouble at their home ground during their Round of 16 second leg against Defensor Sporting.[1]
Independiente 2–2 Deportes Tolima on points. Independiente advanced on away goals.
----Goiás advanced on points 4–1.
----Palmeiras advanced on points 4–1.
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----Independiente 3–3 LDU Quito on points. Independiente advanced on away goals.
----Palmeiras 3–3 Goiás on points. Goiás advanced on away goals.
See main article: 2010 Copa Sudamericana Finals. Note: In the final, the away goals rule would not be applied, and extra time would be played if necessary.
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Independiente 3–3 Goiás on points. Independiente won on penalties.