| Date: | September 6 - 11 |
| Edition: | 13th |
| Location: | Sevilla, Spain |
| Champs: |  Albert Ramos-Viñolas |
| Champd: | Daniel Muñoz de la Nava / Santiago Ventura |
The 2010 Copa Sevilla was a professional tennis tournament played on clay courts. It was the 13th edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Sevilla, Spain between 6 and 11 September.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Spain | Pere Riba | 76 | 1 | |
| Spain | Albert Ramos-Viñolas | 117 | 2 | |
| Spain | Santiago Ventura | 125 | 3 | |
| Rui Machado | 126 | 4 | ||
| Spain | Daniel Muñoz de la Nava | 143 | 5 | |
| Spain | Óscar Hernández | 159 | 6 | |
| Spain | Iván Navarro | 160 | 7 | |
| Spain | Guillermo Olaso | 240 | 8 |
The following players received wildcards into the singles main draw:
Marc López Javier Martí Ismael Rodríguez-Ramos Javier Valenzuela-GonzálezThe following players received entry from the qualifying draw:
Carlos Gómez-Herrera Gerard Granollers-Pujol Pablo Martín-AdaliaSee main article: 2010 Copa Sevilla – Singles. Albert Ramos-Viñolas def. Pere Riba, 6–3, 3–6, 7–5
See main article: 2010 Copa Sevilla – Doubles. Daniel Muñoz de la Nava / Santiago Ventura def. 
Nikola Ćirić / Guillermo Olaso, 6–2, 7–5