| Date: | 27 September – 3 October |
| Edition: | 6th |
| Location: | Montevideo, Uruguay |
| Champs: |  Máximo González |
| Champd: | Carlos Berlocq / Brian Dabul |
The 2010 Copa Petrobras Montevideo was a professional tennis tournament played on outdoor red clay courts. It was the sixth edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Montevideo, Uruguay between 27 September and 3 October 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Pablo Cuevas | 70 | 1 | ||
| Argentina | Brian Dabul | 95 | 2 | |
| Argentina | Carlos Berlocq | 98 | 3 | |
| Rui Machado | 124 | 4 | ||
| Nicolás Massú | 128 | 5 | ||
 Spain | Santiago Ventura | 139 | 6 | |
| Argentina | Federico del Bonis | 148 | 7 | |
| Argentina | Diego Junqueira | 189 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Rafael Camilo Guillermo Durán Jonathan Gonzalia Agustín PiccoSee main article: 2010 Copa Petrobras Montevideo – Singles. Máximo González def. Pablo Cuevas, 1–6, 6–3, 6–4
See main article: 2010 Copa Petrobras Montevideo – Doubles. Carlos Berlocq / Brian Dabul def. Máximo González / Sebastián Prieto, 7–5, 6–3