The 2010 Copa Petrobras Buenos Aires was a professional tennis tournament played on red clay courts. It was the seventh edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 4 and 11 October 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Pablo Cuevas | 69 | 1 | ||
 Italy | Fabio Fognini | 71 | 2 | |
 Argentina | Brian Dabul | 94 | 3 | |
| Argentina | Carlos Berlocq | 97 | 4 | |
| Rui Machado | 124 | 5 | ||
| Nicolás Massú | 128 | 6 | ||
| Ramón Delgado | 135 | 7 | ||
| Argentina | Federico del Bonis | 150 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Juan-Martín Aranguren Andrés Molteni Guido Pella Marco Trungelliti
Cătălin Gârd (Lucky loser replacing Guillermo Alcaide)See main article: 2010 Copa Petrobras Buenos Aires – Singles. Máximo González def. Pablo Cuevas, 6–4, 6–3
See main article: 2010 Copa Petrobras Buenos Aires – Doubles. Carlos Berlocq / Brian Dabul def. Jorge Aguilar / Federico del Bonis, 6–3, 6–2
