See main article: 2010 Copa Petrobras Asunción. The defending champions: Rubén Ramírez Hidalgo and Santiago Ventura were eliminated by Rogério Dutra da Silva and Rui Machado already in the first round.
Italian pair Fabio Fognini and Paolo Lorenzi defeated 4th seeds Carlos Berlocq and Brian Dabul 6–3, 6–4 in the final match.