| Tourney Name: | Commonwealth of Independent States Cup |
| Year: | 2010 |
| Other Titles: | CIS Cup, Кубок Содружества 2010 |
| Country: | Russia |
| Dates: | 16–24 January 2010 |
| Num Teams: | 16 |
| Venues: | 2 |
| Cities: | 1 |
| Champion Other: |  Rubin Kazan |
| Count: | 1 |
| Matches: | 31 |
| Goals: | 91 |
| Top Scorer: |  Emil Kenzhesariyev(6 goals) |
| Prevseason: | 2009 |
| Nextseason: | 2011 |
2010 Commonwealth of Independent States Cup was the eighteenth edition of the competition between the champions of former republics of Soviet Union. It was won by Rubin Kazan for the first time.
| Team | Qualification | Participation | |
|---|---|---|---|
| Rubin Kazan | 2009 Russian Premier League champions 1 | 2nd | |
 Dynamo Kyiv | 2008–09 Ukrainian Premier League champions 2 | 11th | |
 Dnepr Mogilev | 2009 Belarusian Premier League 3rd team 3 | 2nd | |
| Ekranas Panevėžys | 2009 A Lyga champions | 3rd | |
 Liepājas Metalurgs | 2009 Latvian Higher League champions | 2nd | |
 Levadia Tallinn | 2009 Meistriliiga champions | 7th | |
 Dacia Chișinău | 2008–09 Moldovan National Division runners-up 4 | 1st | |
 Pyunik Yerevan | 2009 Armenian Premier League champions 5 | 8th | |
 Baku | 2008–09 Azerbaijan Premier League champions | 2nd | |
 Aktobe | 2009 Kazakhstan Premier League champions | 5th | |
 Bunyodkor Tashkent | 2009 Uzbek League champions 6 | 1st | |
 Vakhsh Qurghonteppa | 2009 Tajik League champions | 3rd | |
 HTTU Aşgabat | 2009 Ýokary Liga champions | 3rd | |
| Dordoi-Dynamo Naryn | 2009 Kyrgyzstan League champions | 6th | |
 HJK Helsinki | 2009 Veikkausliiga champions 7 | 1st | |
| Russia XI | Unofficial entry, not eligible to advance past group stage | 2nd |
WIT Georgia Tbilisi (2008–09 Georgian champions), who declined to participate along with other Georgian teams due to the Russo-Georgian War.----
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| Rank | Player | Team | Goals | |
|---|---|---|---|---|
| 1 | Emil Kenzhesariyev | Aktobe | 6 | |
| align=center rowspan="2" | 2 | Bahodir Nasimov | Bunyodkor Tashkent | 5 |
| Igor Bugaiov | Dacia Chișinău | 5 | ||
| align=center rowspan="2" | 4 | Berdi Şamyradow | HTTU Aşgabat | 4 |
| Andrey Lyasyuk | Dnepr Mogilev | 4 | ||
| align=center rowspan="3" | 6 | Igor Portnyagin | Rubin Kazan | 3 |
| Aleksandr Yarkin | Rubin Kazan | 3 | ||
| Konstantin Golovskoy | Aktobe | 3 |