The 2010 Challenger Salinas Diario Expreso was a professional tennis tournament played on outdoor hard courts. It was part of the 2010 ATP Challenger Tour. It took place in Salinas, Ecuador between 11 and 16 January 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Nicolás Massú | 112 | 1 | ||
| Thiago Alves | 149 | 2 | ||
 Argentina | Sebastián Decoud | 150 | 3 | |
 Colombia | Carlos Salamanca | 158 | 4 | |
| Argentina | Brian Dabul | 168 | 5 | |
 Mexico | Santiago González | 176 | 6 | |
| Argentina | Diego Junqueira | 193 | 7 | |
 Brazil | João Souza | 199 | 8 |
The following players received wildcards into the singles main draw:
Júlio César Campozano
Carlton Fiorentino Jan-Michael Gambill Emilio GómezThe following players received entry from the qualifying draw:
The following player received the lucky loser spot:
See main article: 2010 Challenger Salinas Diario Expreso – Singles.
Brian Dabul def. Nicolás Massú, 6–3, 6–2
See main article: 2010 Challenger Salinas Diario Expreso – Doubles.
Jonathan Marray / Jamie Murray def. 
Sanchai Ratiwatana / Sonchat Ratiwatana, 6–3, 6–4
