| Date: | July 26 – August 1 |
| Edition: | 17th |
| Category: | ATP Challenger Tour |
| Surface: | Hard – outdoors |
| Location: | Granby, Quebec, Canada |
| Venue: | Club de tennis des Loisirs de Granby |
| Champs: | Tobias Kamke |
| Champd: | Frederik Nielsen /  Joseph Sirianni |
| Main Name: | Challenger de Granby |
The 2010 Challenger Banque Nationale de Granby was a professional tennis tournament played on outdoor hard courts. It was the 17th edition of the tournament and part of the 2010 ATP Challenger Tour, offering totals of $50,000 in prize money. It took place in Granby, Quebec, Canada between July 26 and August 1, 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tobias Kamke | 100 | 1 | ||
 Japan | Go Soeda | 113 | 2 | |
 Colombia | Carlos Salamanca | 148 | 3 | |
 Israel | Harel Levy | 156 | 4 | |
| Jesse Levine | 157 | 5 | ||
| Igor Sijsling | 161 | 6 | ||
| Paul Capdeville | 179 | 7 | ||
 Canada | Peter Polansky | 186 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Challenger Banque Nationale de Granby – Singles. Tobias Kamke def. Milos Raonic, 6–3, 7–6(7–4)
See main article: 2010 Challenger Banque Nationale de Granby – Doubles. Frederik Nielsen / Joseph Sirianni def. 
Sanchai Ratiwatana / Sonchat Ratiwatana, 4–6, 6–4, [10–6]
