| Date: | February 13–21 |
| Edition: | 35th (Men) / 25th (Women) |
| Category: | ATP World Tour 500 (men) (women) |
| Location: | Memphis, Tennessee, US |
| Champms: |  Sam Querrey |
| Champws: |  Maria Sharapova |
| Champmd: | John Isner / Sam Querrey |
| Champwd: | Vania King / Michaëlla Krajicek |
The 2010 Regions Morgan Keegan Championships and the Cellular South Cup was an ATP World Tour and WTA Tour event held at the hardcourts of the Racquet Club of Memphis in Memphis, Tennessee, US. It was the 35th edition of the Regions Morgan Keegan Championships and the 25th edition of the Cellular South Cup. The Regions Morgan Keegan Championships was part of the ATP World Tour 500 series on the 2010 ATP World Tour, and the Cellular South Cup was an International-level tournament on the 2010 WTA Tour. The ATP event took place from February 13 to February 21, 2010, and the WTA event from February 12 to February 20.
The men's draw was led by 2009 Wimbledon finalist, 2010 Brisbane International champion and defending champion Andy Roddick, Fernando Verdasco, 2010 Heineken Open champion John Isner, and 2010 Brisbane International runner-up Radek Štěpánek. Other players are Tommy Haas, Philipp Kohlschreiber, and James Blake
The women's draw was headed by former world No. 1 Maria Sharapova, 2009 US Open quarterfinalist Melanie Oudin, homenation player Vania King, Kaia Kanepi, Czechs Lucie Hradecká and Petra Kvitová
| Athlete | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Maria Sharapova | Russia | 16 | 1 | |
| Melanie Oudin | United States | 53 | 2 | |
| Kaia Kanepi |  Estonia | 61 | 3 | |
| Lucie Hradecká |  Czech Republic | 64 | 4 | |
| Petra Kvitová | Czech Republic | 68 | 5 | |
| Kristina Barrois | Germany | 70 | 6 | |
| Vania King | United States | 73 | 7 | |
| Elena Baltacha |  Great Britain | 83 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
| Athlete | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Andy Roddick | United States | 7 | 1 | |
| Fernando Verdasco |  Spain | 11 | 2 | |
| Radek Štěpánek | Czech Republic | 14 | 3 | |
| Tommy Haas | Germany | 17 | 4 | |
| Tomáš Berdych | Czech Republic | 23 | 5 | |
| John Isner | United States | 25 | 6 | |
| Philipp Kohlschreiber | Germany | 29 | 7 | |
| Sam Querrey | United States | 31 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Regions Morgan Keegan Championships – Singles. Sam Querrey defeated John Isner, 6–7(3–7), 7–6(7–5), 6–3
See main article: 2010 Cellular South Cup – Singles. Maria Sharapova defeated 
Sofia Arvidsson, 6–2, 6–1
See main article: 2010 Regions Morgan Keegan Championships – Doubles. John Isner / Sam Querrey defeated Ross Hutchins / 
Jordan Kerr, 6–4, 6–4
See main article: 2010 Cellular South Cup – Doubles. Vania King / Michaëlla Krajicek defeated Bethanie Mattek-Sands / Meghann Shaughnessy, 7–5, 6–2
