| Season: | 2010 |
| Competition: | Cambodian League |
| Winners: | Phnom Penh Crown FC |
| League Topscorer: | Ononiwu Chukwuma (25 goals) |
| Prevseason: | 2009 |
| Nextseason: | 2011 |
The 2010 Cambodian League season is the 26th season of top-tier football in Cambodia. A total of ten teams are competing in the league, with Nagacorp the defending champions. The season started in March.
Post Tel Club and Phuchung Neak were relegated to the second level of Cambodian football, Division 1A after ending the 2009 season in the bottom two places. Promoted from the second level were Chhma Khmao and Prek Pra Keila.
Spark FC were renamed to Wat Phnom.
| Club | Location | Stadium | |
|---|---|---|---|
| Phnom Penh Crown | Phnom Penh | Olympic Stadium | |
| Preah Khan Reach | |||
| Khemara Keila | Phnom Penh | Olympic Stadium | |
| Nagacorp | |||
| Kirivong Sok Sen Chey | Takéo | ||
| National Defense Ministry | Phnom Penh | ||
| Build Bright United | Phnom Penh | ||
| Chhma Khmao | Svay Rieng | ||
| Wat Phnom (Formerly Spark FC) | Phnom Penh | ||
| Prek Pra Keila |
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Champions qualify to 2011 AFC President's Cup.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Julius Chukwuma Ononiwu | Kirivong Sok Sen Chey | 25 |
| 2 | Teab Vathanak | Nagacorp | 21 |
| 3 | Khoun Laboravy | Preah Khan Reach | 16 |
| Justine Uche Prince | Phnom Penh Crown FC | ||
| Nuth Sinoun | Build Bright United | ||
| 6 | Keo Sokngon | Phnom Penh Crown FC | 12 |
| 7 | Sam El Nasa | Preah Khan Reach | 10 |
| 8 | Phlong Chanthou | Wat Phnom FC | 9 |
| Khim Borey | National Defense | ||
| Oladiji Nelson Olatunde | Build Bright United |