The 2010 Calabasas Pro Tennis Championships was a professional tennis tournament played on hard courts. It was the tenth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Calabasas, United States between 18 and 24 October 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Donald Young | 111 | 1 | ||
| Ryan Sweeting | 115 | 2 | ||
| Robert Kendrick | 147 | 3 | ||
 Australia | Carsten Ball | 154 | 4 | |
| Izak van der Merwe | 158 | 5 | ||
| Australia | Marinko Matosevic | 163 | 6 | |
| Kevin Kim | 176 | 7 | ||
| Australia | John Millman | 179 | 8 |
The following players received wildcards into the singles main draw:
Steve Johnson Tim SmyczekThe following players received entry from the qualifying draw:
Nikoloz Basilashvili Daniel Kosakowski Nicholas Monroe
Luís Antonio Pérez-PérezSee main article: article and 2010 Calabasas Pro Tennis Championships – Singles. Marinko Matosevic def. Ryan Sweeting, 2–6, 6–4, 6–3
See main article: article and 2010 Calabasas Pro Tennis Championships – Doubles. Ryan Harrison / Travis Rettenmaier def. Rik de Voest / Bobby Reynolds, 6–3, 6–3