| Sport: | football |
| Team: | Cal Poly Mustangs |
| Year: | 2010 |
| Conference: | Great West Conference |
| Short Conf: | GWC |
| Record: | 7–4 |
| Conf Record: | 2–2 |
| Off Coach: | Brian Cook/Saga Tuitele |
| Def Coach: | Greg Lupfer |
| Stadium: | Alex G. Spanos Stadium |
The 2010 Cal Poly Mustangs football team represented California Polytechnic State University in the 2010 NCAA Division I FCS football season. The team's head coach was Tim Walsh. The Mustangs play their home games at Alex G. Spanos Stadium in San Luis Obispo, California. They finished the season 7–4, 2–2 in Great West Conference play.
See also: 2010 Humboldt State Lumberjacks football team.
See also: 2010 Montana Grizzlies football team.
See also: 2010 Texas State Bobcats football team.
See also: 2010 McNeese State Cowboys football team.
See also: 2010 Fresno State Bulldogs football team. Fresno State outscored Cal Poly 17-0 in the second half in the first meeting between the two rivals since 1985. Bulldogs go to 8-0 vs. FCS/1-AA teams under Pat Hill.
See also: 2010 Old Dominion Monarchs football team.
See also: 2010 Saint Francis Red Flash football team.
See also: 2010 UC Davis Aggies football team.
See also: Battle for the Golden Horseshoe.