| Sport: | football |
| Year: | 2010 |
| Team: | Buffalo Bulls |
| Conference: | Mid-American Conference |
| Short Conf: | MAC |
| Division: | East |
| Record: | 2–10 |
| Conf Record: | 1–7 |
| Hc Year: | 1st |
| Off Coach: | Greg Forest |
| Oc Year: | 1st |
| Dc Year: | 1st |
| Stadium: | University at Buffalo Stadium |
The 2010 Buffalo Bulls football team represented the University at Buffalo in the 2010 NCAA Division I FBS football season. The Bulls, led by first-year head coach Jeff Quinn, played their home games at the University at Buffalo Stadium and members of the east division of the Mid-American Conference. They finished the season 2–10, 1–7 in MAC play.
| Name | Position | Height | Weight | Hometown | |
| Dalton Barksdale | Defensive end | 6'3" | 240 | Detroit, MI | |
| Dante Burton | Tight end | 6'4" | 236 | Lodi, NJ | |
| Jasen Carlson | Offensive lineman | 6'3" | 295 | Lakewood, NY | |
| Andre Davis | Defensive tackle | 6'4" | 275 | Cheektowaga, NY | |
| Cordero Dixon | Wide receiver | 6'1" | 185 | Suwanee, GA | |
| Delano Fabor | Cornerback | 6'0" | 193 | Buffalo, NY | |
| Okoye Houston | Safety | 6'0" | 185 | Greenville, SC | |
| Devon Hughes | Wide Receiver | 6'0" | 185 | Tyrone, GA | |
| Rudy Johnson | Quarterback | 6'1" | 195 | Owings Mills, MD | |
| Cortney Lester | Wide Receiver | 5'11" | 175 | Miramar, FL | |
| Jack Molloy | Punter/Placekicker | 6'2" | 200 | Harrison, NY | |
| James Potts | Running back | 5'11 | 190 | Boynton Beach, FL | |
| Adam Redden | Wide Receiver | 6'0" | 185 | Amherst, NY | |
| Kendall Roberson | Linebacker | 6'2" | 215 | Decatur, GA | |
| Witney Sherry | Safety | 6'1" | 180 | Miami, FL | |
| Jake Silas | Offensive Lineman | 6'8" | 270 | Portland, MI | |
| Kristjan Sokoli | Defensive end | 6'5" | 230 | Bloomfield, NJ | |
| Dwellie Striggles | Cornerback | 5'10" | 170 | Lauderhill, FL | |
| Jeff Veinotte | Offensive Lineman | 6'5" | 305 | Ottawa, ON | |
| Aaron Walters | Wide Receiver | 6'1" | 180 | Hopkins, SC | |
| Tyler Warden | Quarterback | 6'7" | 215 | Glen Ellyn, IL | |
| Colby Way | Linebacker | 6'3" | 235 | State College, PA | |
| Alex Zordich | Quarterback | 6'3" | 215 | Youngstown, OH |
See main article: 2011 NFL draft. The following Bull was selected in the National Football League draft following the season.[1]
| 5 | 143 | Josh Thomas | Defensive backster | Dallas Cowboys |