| Champ: |  Anna Chakvetadze |
| Runner: |  Johanna Larsson |
| Score: | 6–1, 6–2 |
| After Year: | 2021 |
| After Name: | Zavarovalnica Sava Portorož – Singles |
| Type: | singles doubles |
See main article: 2010 Banka Koper Slovenia Open. Dinara Safina was the defending champion, but she chose not to participate.
Anna Chakvetadze won the title, defeating Johanna Larsson in the final, 6–1, 6–2. This was the final WTA singles title that Chakvetadze won before her retirement in 2013.