The 2010 BSI Challenger Lugano was a professional tennis tournament played on outdoor red clay courts. It was part of the Tretorn SERIE+ of the 2010 ATP Challenger Tour. It took place in Lugano, Switzerland between 7 and 13 June 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Stanislas Wawrinka | 24 | 1 | ||
 Italy | Potito Starace | 60 | 2 | |
| Frederico Gil | 100 | 3 | ||
| Rui Machado | 104 | 4 | ||
 Brazil | Thiago Alves | 107 | 5 | |
 Russian Federation | Teymuraz Gabashvili | 114 | 6 | |
| Italy | Filippo Volandri | 118 | 7 | |
 Spain | Alberto Martín | 123 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry a special Exempt into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 BSI Challenger Lugano – Singles. Stanislas Wawrinka def. Potito Starace 6–7(2), 6–2, 6–1
See main article: 2010 BSI Challenger Lugano – Doubles. Frederico Gil / 
Christophe Rochus def. 
Santiago González / 
Travis Rettenmaier, 7–5, 7–6(3)
