The 2010 BCR Open Romania was a men's tennis tournament played on outdoor clay courts. It was the 18th edition of the event known that year as the BCR Open Romania, and was part of the ATP World Tour 250 series of the 2010 ATP World Tour. It was held at the Arenele BNR in Bucharest, Romania, from 20 September through 26 September 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| 22 | 1 | |||
| 45 | 2 | |||
| 50 | 3 | |||
| 51 | 4 | |||
| 53 | 5 | |||
| 54 | 6 | |||
| 58 | 7 | |||
| 59 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as a Lucky loser:
See main article: 2010 BCR Open Romania – Singles. 
Juan Ignacio Chela defeated 
Pablo Andújar, 7–5, 6–1
See main article: 2010 BCR Open Romania – Doubles. Juan Ignacio Chela / 
Łukasz Kubot defeated Marcel Granollers / Santiago Ventura, 6–2, 5–7, [13–11]
