The 2010 Telstra Australian Swimming Championships were held from 16 March to 21 March 2010 in Sydney, New South Wales, Australia. They doubled as the national trials for the 2010 Commonwealth Games and 2010 Pan Pacific Swimming Championships.
| 50 m freestyle | Ashley Callus | 22.09 | Cameron Prosser | 22.36 | Eamon Sullivan | 22.38 | |
| 100 m freestyle | Eamon Sullivan | 48.52 | Tommaso D'Orsogna | 49.35 | James Magnussen | 49.43 | |
| 200 m freestyle | Nic Ffrost | 1:47.50 | Thomas Fraser-Holmes | 1:47.66 | Kenrick Monk | 1:47.83 | |
| 400 m freestyle | Robert Hurley | 3:47.67 | Ryan Napoleon | 3:48.70 | Patrick Murphy | 3:49.43 | |
| 800 m freestyle | Robert Hurley | 7:55.36 | Ryan Napoleon | 7:59.23 | Christopher Ashwood | 8:00.94 | |
| 1500 m freestyle | Robert Hurley | 15:00.96 | Ryan Napoleon | 15:14.96 | Christopher Ashwood | 15:19.39 | |
| 50 m backstroke | Hayden Stoeckel | 25.06 | Daniel Arnamnart | 25.08 | Ben Treffers | 25.09 | |
| 100 m backstroke | Hayden Stoeckel | 53.61 | Ashley Delaney | 54.07 | Ben Treffers | 55.00 | |
| 200 m backstroke | Hayden Stoeckel | 1:58.04 | Ashley Delaney | 1:58.56 | Braiden Camm | 2:00.51 | |
| 50 m butterfly | Geoff Huegill | 23.46 | Andrew Lauterstein | 23.82 | Mitchell Patterson | 23.89 | |
| 100 m butterfly | Andrew Lauterstein | 51.79 | Chris Wright | 52.49 | Adam Pine | 52.57 | |
| 200 m butterfly | Nick D'Arcy | 1:54.61 | Chris Wright | 1:56.23 | Jayden Hadler | 1:57.07 | |
| 50 m breaststroke | Brenton Rickard | 27.40 | Christian Sprenger | 27.95 | Karl Wurzer | 28.40 | |
| 100 m breaststroke | Brenton Rickard | 1:00.19 | Christian Sprenger | 1:00.91 | Nicholas Schafer | 1:02.40 | |
| 200 m breaststroke | Brenton Rickard | 2:09.31 | Craig Calder | 2:12.33 | Christian Sprenger | 2:12.71 | |
| 200 m individual medley | Leith Brodie | 1:59.60 | Thomas Fraser-Holmes | 2:00.84 | Tommaso D'Orsogna | 2:00.90 | |
| 400 m individual medley | Thomas Fraser-Holmes | 4:16.81 | Jayden Hadler | 4:20.79 | Mitch Larkin | 4:21.54 |
| 50 m freestyle | Yolane Kukla | 25.08 | Alice Mills | 25.13 | Cate Campbell | 25.15 | |
| 100 m freestyle | Emily Seebohm | 54.70 | Alicia Coutts | 54.86 | Alice Mills | 55.32 | |
| 200 m freestyle | Blair Evans | 1:57.38 | Bronte Barratt | 1:57.46 | Kylie Palmer | 1:57.69 | |
| 400 m freestyle | Bronte Barratt | 4:05.50 | Kylie Palmer | 4:06.36 | Katie Goldman | 4:07.12 | |
| 800 m freestyle | Katie Goldman | 8:22.83 | Blair Evans | 8:25.74 | Kylie Palmer | 8:29.57 | |
| 1500 m freestyle | Melissa Gorman | 16:03.24 | Kylie Palmer | 16:41.71 | Da DeFrancesco | 16:46.58 | |
| 50 m backstroke | Emily Seebohm | 27.95 | Sophie Edington | 28.20 | Grace Loh | 28.52 | |
| 100 m backstroke | Emily Seebohm | 59.21 | Belinda Hocking | 1:00.11 | Sophie Edington | 1:01.20 | |
| 200 m backstroke | Belinda Hocking | 2:07.89 | Meagen Nay | 2:08.02 | Emily Seebohm | 2:08.19 | |
| 50 m butterfly | Yolane Kukla | 25.92 | Marieke Guehrer | 26.28 | Emily Seebohm | 26.47 | |
| 100 m butterfly | Stephanie Rice | 57.71 | Felicity Galvez | 58.20 | Jessicah Schipper | 58.41 | |
| 200 m butterfly | Jessica Schipper | 2:07.66 | Samantha Hamill | 2:07.75 | Felicity Galvez | 2:08.83 | |
| 50 m breaststroke | Leisel Jones | 30.87 | Leiston Pickett | 31.06 | Sarah Katsoulis | 31.12 | |
| 100 m breaststroke | Leisel Jones | 1:05.79 | Samantha Marshall | 1:07.45 | Sarah Katsoulis | 1:07.89 | |
| 200 m breaststroke | Leisel Jones | 2:23.45 | Sarah Katsoulis | 2:25.35 | Tessa Wallace | 2:28.67 | |
| 200 m individual medley | Stephanie Rice | 2:10.07 | Emily Seebohm | 2:10.75 | Alicia Coutts | 2:11.97 | |
| 400 m individual medley | Stephanie Rice | 4:35.04 | Samantha Hamill | 4:40.44 | Blair Evans | 4:40.49 |