| Champ: |  Peter Norfolk |
| Runner: |  David Wagner |
| Score: | 6–2, 7–6(7–4) |
See main article: 2010 Australian Open.
Two-time defending champion Peter Norfolk defeated David Wagner in the final, 6–2, 7–6(7–4) to win the quad singles wheelchair tennis title at the 2010 Australian Open.
Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.