| Champ: |  Shingo Kunieda |
| Runner: |  Stéphane Houdet |
| Score: | 7–6(7–3), 2–6, 7–5 |
See main article: 2010 Australian Open.
Three-time defending champion Shingo Kunieda defeated Stéphane Houdet in the final, 7–6(7–3), 2–6, 7–5 to win the men's singles wheelchair tennis title at the 2010 Australian Open. It was his fourth Australian Open singles title and ninth major singles title overall.
Shingo Kunieda (champion) Stéphane Houdet (final)