| Champ: |  Mardy Fish |
| Runner: | John Isner |
| Score: | 4–6, 6–4, 7–6(7–4) |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Indianapolis Tennis Championships – Singles |
| After Name: | Atlanta Tennis Championships – Singles |
See main article: 2010 Atlanta Tennis Championships. Robby Ginepri was the defending champion, but lost in the second round to fellow American and eventual champion Mardy Fish. Fish won his second title of 2010 and in July by defeating compatriot John Isner 4–6, 6–4, 7–6(7–4).
The top four seeds receive a bye into the second round.