The 2010 Atlanta Tennis Championships was a men's tennis tournament played on outdoor hard courts. It was the 23rd edition of the event known that year as the Atlanta Tennis Championships and was part of the ATP World Tour 250 series of the 2010 ATP World Tour. The Atlanta Tennis Championships was the first ATP stop of the 2010 US Open Series. 2010 was the first year this tournament was held in Atlanta. Previously, it had been hosted by Indianapolis. Mardy Fish won the singles title.
See main article: 2010 Atlanta Tennis Championships – Singles. 
Mardy Fish defeated John Isner, 4–6, 6–4, 7–6(7–4)
See main article: 2010 Atlanta Tennis Championships – Doubles. Scott Lipsky / Rajeev Ram defeated 
Rohan Bopanna / 
Kristof Vliegen, 6–3, 6–7(4–7), [12–10]
| Player | Nation | Ranking* | Seeding |
|---|---|---|---|
| Andy Roddick | 9 | 1 | |
| John Isner | 18 | 2 | |
| Lleyton Hewitt |  Australia | 31 | 3 |
| Horacio Zeballos |  Argentina | 43 | 4 |
| Janko Tipsarević |  Serbia | 46 | 5 |
| Mardy Fish | 49 | 6 | |
| Xavier Malisse | Belgium | 58 | 7 |
| Benjamin Becker | 67 | 8 | |
| Illya Marchenko |  Ukraine | 68 | |
| Robby Ginepri | United States | 74--> | |
The following players received wildcards into the singles main draw
The following players received entry from the qualifying draw:
