The 2010 Aspria Tennis Cup was a professional tennis tournament played on outdoor red clay courts. It was part of the 2010 ATP Challenger Tour. It took place in Milan, Italy between 14 and 20 June 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Frederico Gil | 98 | 1 | ||
 Italy | Filippo Volandri | 103 | 2 | |
 Kazakhstan | Mikhail Kukushkin | 131 | 3 | |
 Spain | Rubén Ramírez Hidalgo | 132 | 4 | |
| Spain | Alberto Martín | 138 | 5 | |
| Spain | Pablo Andújar | 139 | 6 | |
 Argentina | Federico del Bonis | 146 | 7 | |
 Romania | Adrian Ungur | 155 | 8 |
The following players received wildcards into the singles main draw:
Fabio Colangelo Enrico Fioravante Roberto Marcora Gianluca NasoThe following players received entry from the qualifying draw:
Evgeny Donskoy
Bruno RodríguezSee main article: 2010 Aspria Tennis Cup – Singles. Frederico Gil def. Máximo González, 6–1, 7–5
See main article: 2010 Aspria Tennis Cup – Doubles. Daniele Bracciali / Rubén Ramírez Hidalgo def. 
James Cerretani / Jeff Coetzee, 6–4, 7–5