| Date: | August 9 – August 15 |
| Edition: | 24th |
| Location: | Istanbul, Turkey |
| Champs: |  Adrian Mannarino |
| Champd: |  Leoš Friedl /  Dušan Vemić |
The 2010 American Express – TED Open was a professional tennis tournament played on outdoor hard courts. It was the twenty-fourth edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Istanbul, Turkey between 9 and 15 August 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Belgium | Olivier Rochus | 66 | 1 | |
| Frederico Gil | 81 | 2 | ||
 Kazakhstan | Mikhail Kukushkin | 91 | 3 | |
 Jamaica | Dustin Brown | 99 | 4 | |
 Turkey | Marsel İlhan | 106 | 5 | |
 Romania | Adrian Ungur | 123 | 6 | |
 Russian Federation | Igor Kunitsyn | 124 | 7 | |
 Austria | Martin Fischer | 130 | 8 |
The following players received wildcards into the singles main draw:
Haluk Akkoyun Tuna Altuna Marsel İlhanThe following players received a Special Exempt into the singles main draw:
The following players received entry from the qualifying draw:
Arsen Asanov
Javier Martí
Filip PrpicSee main article: 2010 American Express – TED Open – Singles. Adrian Mannarino def. Mikhail Kukushkin, 6–4, 3–6, 6–3
See main article: 2010 American Express – TED Open – Doubles. Leoš Friedl / Dušan Vemić def. 
Brian Battistone / Andreas Siljeström, 7–6(6), 7–6(3)