| Year: | 2010 |
| Team: | Alabama State Hornets |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Short Conf: | SWAC |
| Division: | East Division |
| Record: | 7–5 |
| Conf Record: | 6–3 |
| Head Coach: | Reggie Barlow |
| Hc Year: | 4th |
| Off Coach: | Melvin Spears |
| Oc Year: | 1st |
| Def Coach: | Cedric Thornton |
| Dc Year: | 1st |
| Stadium: | Cramton Bowl |
| Champion: | SWAC East Division co-champion |
| Conf Champ: | SWAC Championship Game |
| Conf Champ Result: | L 6–11 vs. Texas Southern |
The 2010 Alabama State Hornets football team represented Alabama State University as a member of the Southwestern Athletic Conference (SWAC) during the 2010 NCAA Division I FCS football season. Led by fourth-year head coach Reggie Barlow, the Hornets compiled an overall record of 7–5, with a mark of 6–3 in conference play, finished as SWAC East Division co-champion, and lost to Texas Southern in the SWAC Championship Game.