The women's 4 × 400 metres relay at the 2010 African Championships in Athletics was held on August 1.
| Rank | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|
| Shade Abugan, Margaret Etim, Bukola Abogunloko, Ajoke Odumosu | 3:29.26 | ||||
| Grace Miroyo Kidake, Catherine Nandi, Maureen Jelagat Maiyo, Janeth Jepkosgei | 3:35.12 | ||||
| Ndeye Fatou Soumah, Fatou Diabaye, Marietou Badji, Amy Mbacké Thiam | 3:35.55 | ||||
| 4 | Nthompe Seonyatseng, Amantle Montsho, Kgalalelo Sefo, Oarabile Babolayi | 3:37.17 | NR | ||
| 5 | Mantegbosh Melese, Wesene Belay, Emebet Fikadu, Fantu Megso | 3:40.44 | NR | ||
| 6 | Justine Bayigga, Mildred Gamba, Agnes Aneno, Emily Nanziri | 3:41.24 | |||
| Fanny Appes Ekanga, Delphine Atangana, Nathalie Itok, Charlotte Mebenga Amombo | |||||
| Rosina Amenebede, Elizabeth Amolofo, Janet Amponsah, Beatrice Gyaman |