The women's 4 x 100 metres relay at the 2010 African Championships in Athletics was held on July 30.
| Rank | Lane | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|---|
| 3 | Lawretta Ozoh, Agnes Osazuwa, Damola Osayemi, Blessing Okagbare | 43.45 | ||||
| 5 | Fanny Appes Ekanga, Charlotte Mebenga Amombo, Carole Made Kaboud Mebam, Delphine Atangana | 44.90 | ||||
| 5 | Rosina Amenebede, Elizabeth Amolofo, Beatrice Gyaman, Flings Owusu-Agyapong | 45.40 | ||||
| 4 | 4 | Mantegbosh Melese, Fetiya Kedir, Leaynet Alemu, Fantu Magiso | 46.46 | NR | ||
| 5 | 7 | Maryline Chelagat, Grace Miroyo Kidake, Catherine Nandi, Milcent Ndoro | 46.53 | |||
| 2 | Stephanie Guillaume, Mary Jane Vincent, Elodie Pierre Louis, Joanillia Januier |