The men's 4 x 400 metres relay at the 2010 African Championships in Athletics was held between July 31–August 1.
| width=200 valign=top | Geoffrey Ngeno Vincent Kiplangat Koskei Julius Kirwa Mark Kiprotich Mutai | width=200 valign=top | Isaac Makwala Thapelo Ketlogetswe Pako Seribe Obakeng Ngwigwa Tiroyaone Masake | width=200 valign=top | Saul Weigopwa James Godday Tobi Ogunmola Isah Salihu |
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 1 | 3:04.21 | Q | |||
| 2 | 1 | 3:07.71 | Q | |||
| 3 | 2 | 3:08.86 | Q | |||
| 4 | 1 | 3:09.20 | Q | |||
| 5 | 2 | 3:09.87 | Q | |||
| 6 | 1 | 3:10.11 | q | |||
| 7 | 2 | 3:10.28 | Q | |||
| 8 | 1 | 3:16.00 | q | |||
| 9 | 1 | 3:21.01 | NR | |||
| 10 | 2 | 3:26.47 | ||||
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| Rank | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|
| Geoffrey Ngeno, Vincent Kiplangat Koskei, Julius Kirwa, Mark Kiprotich Mutai | 3:02.96 | ||||
| Isaac Makwala, Thapelo Ketlogetswe, Pako Seribe, Obakeng Ngwigwa | 3:05.16 | ||||
| Saul Weigopwa, James Godday, Tobi Ogunmola, Isah Salihu | 3:06.53 | ||||
| 4 | Sadam Koumi, Abubaker Kaki, Hafz Hussein, Rabah Yousif | 3:08.52 | |||
| 5 | Amadou Ndiaye, Abdourahmane N'Dour, Mor Seck, Mamadou Gueye | 3:08.94 | |||
| 6 | Habtamu Gobe, Hago Tadesse, Bereket Desta, Fikadu Dejene | 3:08.96 | |||
| 7 | Anthony Okiror, Ali Ngaimoko, Ramadhan Akula, Emmanuel Tugumisirize | 3:09.41 | |||
| 8 | Augustino Mande, Laurent Masatu, Kassim Hussein Salehe, Frank Martin | 3:16.03 |