The men's 4 x 100 metres relay at the 2010 African Championships in Athletics was held on July 29–30.
| width=200 valign=top | Hannes Dreyer Simon Magakwe Lehann Fourie Thuso Mpuang | width=200 valign=top | Fred Agbaje Benjamin Adukwu Ogho-Oghene Egwero Obinna Metu | width=200 valign=top | Emmanuel Kubi Nana Kofi Sanah Godwin Hukporti Aziz Zakari |
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 39.30 | Q | ||||
| 2 | 39.50 | Q | ||||
| 2 | 39.54 | Q | ||||
| 1 | 39.83 | Q | ||||
| 1 | 40.00 | Q | ||||
| 2 | 40.12 | Q | ||||
| 2 | 40.25 | q | ||||
| 1 | 40.94 | q | ||||
| 1 | 41.17 | |||||
| 10 | 2 | 41.23 | ||||
| 2 | ||||||
| 2 | ||||||
| 1 | ||||||
| 1 |
| Rank | Lane | Nation | Competitors | Time | Notes | |
|---|---|---|---|---|---|---|
| 3 | Hannes Dreyer, Simon Magakwe, Lehann Fourie, Thuso Mpuang | 39.12 | ||||
| 6 | Fred Agbaje, Benjamin Adukwu, Ogho-Oghene Egwero, Obinna Metu | 39.22 | ||||
| 4 | Emmanuel Kubi, Nana Kofi Sanah, Godwin Hukporti, Aziz Zakari | 39.31 | ||||
| 4 | 5 | Simon Kimaru, Anderson Mureta Mutegi, Stephen Barasa, Kipkemoi Soy | 39.40 | NR | ||
| 5 | 7 | Bastute Brasse, Eric Milazar, Fabrice Coiffic, Garick Maureemootoo | 40.27 | |||
| 6 | 8 | Siapade Darius Loua, Ben Youssef Meité, Dazi Conet Theodore Kouassi, Wilfried Koffi Hua | 40.77 | |||
| 7 | 1 | Titus Kafunda, Jack Ng'umbi, Saviour Kombe, Richard Chitambi | 41.22 | |||
| 2 | Siaka Son, Lanssene Relwende Zongo, Innocent Bologo, Gérard Kobéané |