| Champ: |  Li Na |
| Runner: |  Maria Sharapova |
| Score: | 7–5, 6–1 |
| Draw: | 56 (8 / 5) |
| Seeds: | 16 |
| Type: | singles doubles |
| Main Name: | Birmingham Classic (tennis) Birmingham Classic |
See main article: 2010 Aegon Classic. Magdaléna Rybáriková was the defending champion, but lost in the third round to Sesil Karatantcheva.
Li Na won the title defeating Maria Sharapova in the final 7–5, 6–1. This was the only title Li won on grass throughout her career.
The top eight seeds receive a bye into the second round.