The 2010 ATP Salzburg Indoors was a professional tennis tournament played on indoor hard courts. It was the second edition of the tournament which is part of the 2010 ATP Challenger Tour and the Tretorn SERIE+ series. It took place in Salzburg, Austria between 15 and 21 November 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Mischa Zverev | 82 | 1 | ||
 Slovakia | Karol Beck | 99 | 2 | |
| Björn Phau | 104 | 3 | ||
 Austria | Andreas Haider-Maurer | 116 | 4 | |
| Julian Reister | 117 | 5 | ||
| Austria | Martin Fischer | 124 | 6 | |
| Denis Gremelmayr | 133 | 7 | ||
 Ireland | Conor Niland | 156 | 8 |
The following players received wildcards into the singles main draw:
The following player received a Special Exempt into the singles main draw:
The following players received entry from the qualifying draw:
Riccardo Ghedin
Laurynas Grygelis
Boris PašanskiSee main article: 2010 ATP Salzburg Indoors – Singles. Conor Niland def. 
Jerzy Janowicz, 7–6(5), 6–7(2), 6–3
See main article: 2010 ATP Salzburg Indoors – Doubles. Alexander Peya / Martin Slanar def. 
Rameez Junaid / Frank Moser, 7–6(1), 6–3