The 2010 Aegon Pro-Series Loughborough was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Loughborough, Great Britain between 8 and 14 November 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Björn Phau | 95 | 1 | ||
 France | Adrian Mannarino | 97 | 2 | |
 Austria | Andreas Haider-Maurer | 115 | 3 | |
| France | David Guez | 144 | 4 | |
 Ireland | Conor Niland | 156 | 5 | |
 Australia | Matthew Ebden | 168 | 6 | |
 Italy | Simone Vagnozzi | 178 | 7 | |
| Michael Lammer | 204 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Aegon Pro-Series Loughborough – Men's singles. Matthias Bachinger def. Frederik Nielsen, 6–3, 3–6, 6–1
Lara Michel def. 
Anna Fitzpatrick, 6–2, 6–2
See main article: 2010 Aegon Pro-Series Loughborough – Men's doubles. 
Henri Kontinen / Frederik Nielsen def. Jordan Kerr / Ken Skupski, 6–2, 6–4
Jocelyn Rae / Jade Windley def. 
Jana Jandová / Petra Krejsová, 6–3, 5–7, [10–4]