| Competition: | Guy Walmsley & Co Welsh National League |
| Season: | 2010–11 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Guy Walmsley & Co Welsh National League is the sixty-sixth season of the Welsh National League (Wrexham Area). The league began on 14 August 2010 and finished on 20 May 2011.
| Competition: | Guy Walmsley & Co Welsh National League Premier Division |
| Winners: | Penycae |
| Promoted: | Penycae |
| Relegated: | Lex XI |
| Biggest Home Win: | Lex XI 7–1 Llay Welfare 14 August 2010 Venture Community 6–0 Llay Welfare 23 April 2011 Penycae 7–1 Johnstown Youth 26 April 2011 |
| Biggest Away Win: | Lex XI 0–12 FC Cefn 14 May 2011 |
| Highest Scoring: | Lex XI 0–12 FC Cefn 14 May 2011 |
| Matches: | 240 |
| Total Goals: | 974 |
| Competition: | Guy Walmsley & Co Welsh National League Division One |
| Winners: | Penyffordd |
| Promoted: | Penyffordd |
| Biggest Home Win: | Saltney Town 11–0 Hawkesbury Villa 11 December 2010 Llanuwchllyn 11–0 Hawkesbury Villa 14 May 2011 |
| Biggest Away Win: | Glyn Ceiriog 0–7 Penyffordd 16 April 2011 |
| Highest Scoring: | Saltney Town 12–2 Castell Alun Colts 28 August 2010 |
| Matches: | 156 |
| Total Goals: | 698 |