| Competition: | MacWhirter Welsh League Division Two |
| Season: | 2010–11 |
| Winners: | Ton Pentre |
| Promoted: | Cwmaman Institute Ton Pentre AFC Porth |
| Relegated: | Abertillery Bluebirds AFC Llwydcoed Llangeinor |
| Biggest Home Win: | Ton Pentre 7–0 Abertillery Bluebirds 2 October 2010 Croesyceiliog 8–1 Llangeinor 20 April 2011 Ton Pentre 7–0 Ely Rangers 20 April 2011 |
| Biggest Away Win: | Llangeinor 1–7 Ammanford 20 November 2010 Llangeinor 1–7 Ton Pentre 19 February 2011 Llangeinor 2–8 Abertillery Bluebirds 9 April 2011 Llangeinor 1–7 Cwmaman Institute 23 April 2011 Llangeinor 0–6 Newport YMCA 10 May 2011 |
| Highest Scoring: | Ton Pentre 8–2 Llangeinor 30 October 2010 Llangeinor 2–8 Abertillery Bluebirds 9 April 2011 |
| Matches: | 240 |
| Total Goals: | 845 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Welsh Football League Division Two began on 1 September 2010 and ended on 28 May 2011. Ton Pentre won the league by 13 points.
Caerau (Ely), Cwmbran Celtic and Penrhiwceiber Rangers were promoted to the Welsh Football League Division One.
Bettws, Caerleon, Dinas Powys, Ely Rangers and Ton Pentre were relegated from the Welsh Football League Division One.
Cardiff Grange Harlequins, Cwmbran Town, Llanwern, Porthcawl Town Athletic, Tredegar Town and UWIC were relegated to the Welsh Football League Division Three.
Aberbargoed Buds, Abertillery Bluebirds and Cwmaman Institute were promoted from the Welsh Football League Division Three.
Maesteg Park resigned from the league.