| Competition: | MacWhirter Welsh League Division One |
| Season: | 2010–11 |
| Winners: | Bryntirion Athletic |
| Relegated: | Caldicot Town Garden Village Penrhiwceiber Rangers |
| Promoted: | Afan Lido |
| Biggest Home Win: | Bridgend Town 7–0 Caerau (Ely) 29 September 2010 West End 7–0 Penrhiwceiber Rangers 30 October 2010 Caerau (Ely) 7–0 Cardiff Corinthians 19 February 2011 |
| Biggest Away Win: | Penrhiwceiber Rangers 0–7 Bridgend Town 18 September 2010 Cwmbran Celtic 0–7 Bryntirion Athletic 22 January 2011 Aberaman Athletic 0–7 Pontardawe Town 2 February 2011 |
| Highest Scoring: | Taff's Well 5–4 Aberaman Athletic 6 October 2010 |
| Matches: | 240 |
| Total Goals: | 843 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Welsh Football League Division One began on 1 September 2010 and ended on 28 May 2011. Bryntirion Athletic won the league by five points.
Caerau (Ely), Cwmbran Celtic and Penrhiwceiber Rangers were promoted from the Welsh Football League Division Two.
Bettws, Caerleon, Dinas Powys, Ely Rangers and Ton Pentre were relegated to the Welsh Football League Division Two.