The 2010–11 Spartan South Midlands Football League season was the 14th in the history of Spartan South Midlands Football League a football competition in England.
| Competition: | Spartan South Midlands Football League Premier Division |
| Season: | 2010–11 |
| Winners: | Chalfont St Peter |
| Promoted: | Chalfont St Peter |
| Relegated: | Kentish Town Langford |
| Matches: | 506 |
| Total Goals: | 1798 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The Premier Division featured 19 clubs which competed in the division last season, along with four new clubs:
Also, Kingsbury London Tigers changed name to London Tigers.
| Competition: | Spartan South Midlands Football League Division One |
| Season: | 2010–11 |
| Winners: | Berkhamsted |
| Promoted: | Berkhamsted AFC Dunstable |
| Matches: | 420 |
| Total Goals: | 1611 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
Division One featured 17 clubs which competed in the division last season, along with five new clubs:
| Competition: | Spartan South Midlands Football League Division Two |
| Season: | 2010–11 |
| Winners: | Padbury United |
| Matches: | 210 |
| Total Goals: | 888 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
Division Two featured 14 clubs which competed in the division last season, along with two new clubs: