| Competition: | Slovenian Second League |
| Season: | 2010–11 |
| Winners: | Aluminij |
| Promoted: | Mura 05 |
| Relegated: | Drava Ptuj |
| League Topscorer: | Ladislav Stanko (16 goals) |
| Matches: | 135 |
| Total Goals: | 376 |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Slovenian Second League season began on 8 August 2010 and ended on 29 May 2011. Each team played a total of 27 matches.
| Club | Location | Stadium | |
|---|---|---|---|
| Aluminij | Kidričevo | Aluminij Sports Park | |
| Bela Krajina | Črnomelj | ŠRC Loka | |
| Dob | Dob | Dob Sports Park | |
| Drava Ptuj | Ptuj | Ptuj City Stadium | |
| Dravinja | Slovenske Konjice | Dobrava Stadium | |
| Interblock | Ljubljana | ŽŠD Ljubljana | |
| Krško | Krško | Matija Gubec Stadium | |
| Mura 05 | Fazanerija | ||
| Šenčur | Šenčur | Šenčur Sports Park | |
| Šmartno 1928 | Šmartno ob Paki | Šmartno Stadium |