| Season: | 2010–11 |
| League Topscorer: | Slobodan Dinčić (21 goals) |
| Biggest Home Win: | Novi Sad 6–0 Dinamo Vranje |
| Highest Scoring: | Sinđelić Niš 5–2 Kolubara |
| Total Goals: | 665 |
| Matches: | 306 |
| Nextseason: | 2011–12 |
The 2010–11 Serbian First League was the sixth season of the league under its current name. It started on 14 August 2010 and concluded on 15 June 2011.
BASK won the title and Radnički 1923 finished as runners-up, with both clubs earning promotion to the top flight. BASK later ceded its 2011–12 Serbian SuperLiga spot to third-placed Novi Pazar for financial reasons and was administratively relegated to the Serbian League Belgrade, which saw Kolubara avoid relegation.[1]
Zemun, Big Bull Radnički and Dinamo Vranje were relegated to their respective Serbian League groups.
| Pos | Scorer | Team | Goals | |
|---|---|---|---|---|
| 1 |  Slobodan Dinčić | BASK | 21 | |
| 2 | Darko Spalević | Radnički 1923 | 19 | |
| 3 |  Miloš Đalac | Novi Pazar | 14 | |
| 4 | Ognjen Damnjanović | Proleter Novi Sad | 13 | |
| Rodoljub Paunović | BASK | |||
| 6 | Saša Bogunović | Novi Sad | 12 | |
| Zoran Stojanović | Kolubara | |||
| Nikola Vujošević | Zemun | |||
| 9 | Milan Vukašinović | Mladi Radnik | 11 |